Invitro Cytotoxic and Anti – Cancer Studies of Polyvinyl Alcohol Mediated 5fluorouracil Conjugated Gold Nanoparticles
Akhila Rajan1, Praseetha P. K2, Ariharan V. N3, Gopu Kumar S.T4

1Akhila Rajan, Department of Nanotechnology, Noorul Islam Centre For Higher Education, Kumaracoil (Tamil Nadu), India.
2Praseetha P. K, Department of Nanotechnology, Noorul Islam Centre For Higher Education, Kumaracoil (Tamil Nadu), India.
3Ariharan V. N, Department of Bioinformatics Division, Inbiotics, William Hospital Campus, Nagrcoil (Tamil Nadu), India.
4Gopu Kumar S.T, Department of Premedical Science, Thampi Institute of Medical Educational and Research, William Hospital Campus, Nagercoil (Tamil Nadu), India.
Manuscript received on 02 May 2019 | Revised Manuscript received on 14 May 2019 | Manuscript Published on 23 May 2019 | PP: 127-143 | Volume-7 Issue-6S5 April 2019 | Retrieval Number: F10210476S519/2019©BEIESP
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Abstract: Chitosan is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (DE acetylated unit) and N-acetyl-D-glucosamine (acetylated unit). It is made by treating the chitin shells of shrimp and other crustaceans with an alkaline substance, like sodium hydroxide. Chitosan has a number of commercial and possible biomedical uses. Chitosan’s properties also allow it to be used in transdermal drug delivery. Delivering therapeutic compound to the desirable site is a major problem in treatment of many diseases The combination of nanoparticles with chitosan in the form of Nano composite matrices provide the high surface area required to achieve a high loading of enzymes, drugs, and a compatible micro-environment to facilitate stability. Chitosan Nanoparticles (NPs) was prepared using ionic gelation method.5’ Fluorouracil (5’FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against various cell lines (MCF7,A549,AGS, and HT29).
Keywords: Mediated Alcohol Studies Invitro Compound Composite.
Scope of the Article: Nano Technology