Disease Gene Identification Using Reliable Robust Classifier
V. Murugesan1, P. Balamurugan2
1V. Murugesan, Department of Computer Science, VLB Janaki ammal College of Arts and Science, Coimbatore, (Tamil Nadu), India.
2P. Balamurugan, Department of Computer Science, Government Arts College, Coimbatore, (Tamil Nadu), India.
Manuscript received on 13 March 2019 | Revised Manuscript received on 20 March 2019 | Manuscript published on 30 March 2019 | PP: 70-74 | Volume-7 Issue-6, March 2019 | Retrieval Number: E2105017519/19©BEIESP
Open Access | Ethics and Policies | Cite | Mendeley | Indexing and Abstracting
© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Identification of genes causing the diseases is a major challenging problem towards diagnosing and providing treatment in a earlier manner. Many motivating methodologies are being proposed for the identification of disease genes. Generally, the unique variation among the previously proposed methodologies depend on the prior knowledge, also machine learning methodologies utilized for identifying. Identification of disease gene is normally observed as two class classification issue. Nature of information generates a key issue which can have an effect on results. In this research work, reliable robust classifier (RRC) based on dual simplex concept has been proposed to allocate a genes to a single disease class. RRC classifies the genes of classes into vertices of dimension dual simplex which results in -class classification turn out to be class task. Since there exist no benchmark method to characterize the genes that have-diseases and not-have-diseases, this research work utilizes support vector machine to predict it. The results of experiments clearly demonstrate the effectiveness of the method with better precision, recall, and F-measure respectively.
Keywords: Classification, Disease, Gene, Mining, SVM, simplex
Scope of the Article: Classification.