A Clinical Evaluation of an Anti-Aging Cosmetics Containing Functional Peptides and an Epidermal Penetrating Peptide
Young Il Kwon1, Hoon Cha2, Su In Park3, Gyu Min An4, Gyu Ri Kim5, Moon Sam Shin6

1Young Il Kwon, R&D Center, Dermafirm Co., Ltd., Seongnam, Korea.
2Hoon Cha, R&D Center, Dermafirm Co., Ltd., Seongnam, Korea.
3Su In Park, Department of Senior Healthcare, Eulji University Seongnam, Korea.
4Gyu Min An, Department of Senior Healthcare, Eulji University, Seongnam, Korea.
5Gyu Ri Kim, Department of Beauty and Cosmetic Science, Eulji University, Seongnam, Korea.
6Moon Sam Shin, Department of Senior Healthcare, Eulji University Seongnam, Korea.
Manuscript received on 08 May 2019 | Revised Manuscript received on 19 May 2019 | Manuscript Published on 23 May 2019 | PP: 1252-1257 | Volume-7 Issue-6S5 April 2019 | Retrieval Number: F12160476S519/2019©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: Despite considerable interest and research on the efficacy of peptides, clinical and academic studies are yet to demonstrate that their components reduce wrinkles. The purpose of the present study was to investigate the effects of anti-aging peptides; copper glycine-histidine-lysine (Cu-GHK), glycine-histidine-lysine (GHK), palmitoyl oligopeptide-1 (Pal-GHK), palmitoyl pentapeptide-4 (Pal-KTTKS), palmitoyl tetrapeptide-3 (Pal-GQPR), acetyl hexapeptide and a skin penetrating peptide (arginine oligomer peptide, R6) on human skin, by analyzing the effects of a cosmetic formulation containing this substance in terms of skin wrinkle (Antera 3D), skin brightness (Chromameter CR400) and skin melanin measurement (Mexameter MX18). A clinical efficacy test was conducted on 23 adult women aged 30 to 60 years and 3 subjects dropped out of the study so a total of 20 subjects were tested. Wrinkles of the eyes and melanin pigments of the skin significantly decreased, and skin brightness significantly increased after 4 weeks of using the test product (p<0.05). No side effects, such as erythema, edema, scaling, itching, tingling, burning sensation, rashes, and thorns, were observed. Therefore, the test products (Biotoc Regen Cosmetics) containing wrinkle improving peptides (Cu-GHK, GHK, Pal-GHK, Pal-KTTKS, Pal-GQPR, acetyl hexapeptide) and a skin penetrating peptide (arginine oligomer, R6) are considered to have beneficial effects on improvement of skin wrinkle, skin brightness, skin melanin of 4 weeks use.
Keywords: Anti-wrinkle Cosmetics, Epidermal Penetrating Peptide, Clinical Evaluation, Functional Peptides.
Scope of the Article: Performance Evaluation of Networks