Antimicrobial, Anticancer, Antioxidant Potential of Pyridine based Coordination Compounds: in-silico ADMET Prediction and Molecular Docking Simulations
S. Syed Ali Fathima1, E.R. Nagarajan2

1S. Syed Ali Fathima, Department of Chemistry, Kalasalingam Academy of Research and Education College, Krishnankoil (Tamil Nadu), India.
2E. R. Nagarajan, Department of Chemistry, Kalasalingam Academy of Research and Education College, Krishnankoil (Tamil Nadu), India.
Manuscript received on 01 December 2019 | Revised Manuscript received on 19 December 2019 | Manuscript Published on 31 December 2019 | PP: 505-511 | Volume-8 Issue-4S2 December 2019 | Retrieval Number: D11621284S219/2019©BEIESP | DOI: 10.35940/ijrte.D1162.1284S219
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: The novel Schiff base metal complexes were derived from the reaction of 9-anthraldehyde and 2-amino-3-hydroxypyridine and metal chlorides All the compounds were investigated by various spectral analysis. From the analysis, it is clear that compounds have square planar geometry with crystalline look. The DNA synergic studies suggest that the compounds were better DNA binder. The synthesized compounds were screened against several microbes which specified that the compounds have greater screening ability than ligand due to chelation. The anticancer activity of the synthesized compounds was also studied which revealed that the Cu(II) has greater potential rather than other compounds. The antioxidant ability display that the synthesized compounds have excellent ability to destroy the free radical than ligand. The ADMET evaluation shows that the prepared compounds hold good drug-likeness skill.
Keywords: DNA Synergy, Electrophoresis, Metal Compounds, Square Planar.
Scope of the Article: Bio-Science and Bio-Technology