Mathematical Modelling and Analysis of Nanobio-Sensors for Automated Disease Detection and Drug Delivery System
B.N. Shobha1, N.J.R. Muniraj2
1B.N.Shobha, Department of ECE, Sapthagiri College of Engineering, Bangalore (Karnataka), India.
2N.J.R. Muniraj, M.E. Student, Tejaa Shakthi Institute of Technology for Women, Karumathampatti, Coimbatore (Tamil Nadu), India.
Manuscript received on 18 October 2012 | Revised Manuscript received on 25 October 2012 | Manuscript published on 30 October 2012 | PP: 14-19 | Volume-1 Issue-4, October 2012 | Retrieval Number: D0318091412/2012©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Nano-medicine is the medical use of molecular-sized particles to deliver drugs, heat, light or other substances to specific cells in the human body. Engineering particles to be used in this way allows detection and/or treatment of diseases or injuries within the targeted cells, thereby minimizing the damage to healthy cells in the body. Nanomedicine, it is the innovative combination of nanotechnology and medicine providing us with the most modern cutting edge tool in the field of medicine. It has triggered a whirlwind of medical revolution across the globe. In this paper, the mathematical models required to describe the functionality of nanodevices have been reviewed and mathematical model sensor equivalent circuits have been developed. An experimental setup is developed to analyze the characteristics of IS Field Effect Transistor (ISFET), nanowire and nanosphere devices. The impact of geometrical properties on device performance is estimated based on the experimental setup. Settling time and surface analyte concentration graphs obtained using the experimental setup is used in designing a nanobio-sensor for disease detection. Based on the test results, a mathematical model has been developed in Matlab to model nanodevices. Three different iterations of sensor models are carried out based on the results obtained; curve fitting techniques are adopted to generalize the developed sensor model using Savitzky-Golay Filter (SG Filter). The sensors modeled can be used for automated drug detection and delivery unit
Keywords: Nanobio Sensor, Drug Delivery, Cancer Detection, Diffusion Capture
Scope of the Article: Sensor Networks