Hepatoprotective Activity of whole Plant Extract of Catharanthus Pusillus (Murr.) G.Don (Apocynaceae)
Yokeswari Nithya1, P Ananthi2, S Mohan, V.R3

1Yokeswari Nithya, Department of Chemistry, A.P.C. Mahalaxmi College for Women, Thoothukudi (Tamil Nadu), India.
2P Ananthi, Department of Chemistry, Vidhya Sagar Women’s College, Chengalpattu (Tamil Nadu), India.
3S Mohan, V. R, Professor, Department of Biomedical Science and Technology, Noorul Islam Centre for Higher Education, Kumaracoil, Thukalay (Tamil Nadu), India.
Manuscript received on 26 November 2019 | Revised Manuscript received on 07 December 2019 | Manuscript Published on 16 December 2019 | PP: 443-448 | Volume-8 Issue-3S3 November 2019 | Retrieval Number: C10771183S319/2019©BEIESP | DOI: 10.35940/ijrte.C1077.1183S319
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: CCl4 intoxicated rats showed significant elevation in serum enzymes, bilirubin and lipid per oxidation of the liver tissues and reduction in serum total protein, superoxide dismutase, catalase, reduced glutathione and glutathione peroxidase activity. Treatment with ethanol extract of Catharanthus pusillus whole plant altered the above parameters to the levels of near normal. All the above results were comparable with the standard drug silymarin (100mg/kg) treated group. Thus the present study ascertains that the ethanol extract of Catharanthus pusillus whole plant possesses significant hepatoprotective activity.
Keywords: Catharanthus Pusillus, Ccl4, Silymarin, Bilirubin.
Scope of the Article: Bio-Science and Bio-Technology