Antitumor Effect of Fever Range Whole Body Hyperthermia with Curcumin in Breast Cancer-induced Mice
Hanim Saim1, Maheza Irna Mohamad Salim2, Khairunadwa Jemon3
1Hanim Saim, School of Biomedical Engineering & Health Science, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, Johor.
2Maheza Irna Mohamad Salim, School of Biomedical Engineering & Health Science, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, Johor.
3Khairunadwa Jemon, Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Skudai Johor.
Manuscript received on 27 June 2019 | Revised Manuscript received on 15 July 2019 | Manuscript Published on 26 July 2019 | PP: 297-301 | Volume-8 Issue-2S2 July 2019 | Retrieval Number: B10520782S219/2019©BEIESP | DOI: 10.35940/ijrte.B1052.0782S219
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Breast cancer is a complex and heterogeneous disease and also one of the major cancer types among female worldwide. Fever range whole-body hyperthermia and curcumin as a single treatment have been tested against breast cancer and showed some promising anti-tumor effect. However, their combination as an effective anti- tumor treatment against breast cancer has never been explored. The effects of combined wholebody fever range hyperthermia and curcumin on tumor growth was examined in this study. Mice were inoculated with EMT6 cells subcutaneously and allocated to 4 treatment groups: (i) control (control), (ii) curcumin (50mg/kg bodyweight), (iii) twice fever range whole-body hyperthermia 39.0°C (± 0.5) for 15 minutes, (iv) a combination of curcumin (50mg/kg bodyweight) and twice fever range whole-body hyperthermia 39.0°C (± 0.5) for 15 minutes. Following treatment, mice body weight and tumor volume were measured. The greatest tumor growth inhibition exhibited in combination treatment (68.45%, p<0.05) and showed no general toxicity. As conclusion, the combination treatment can be a potential anti-tumor treatment of breast cancer.
Keywords: Breast Cancer, Curcumin, Fever-Range Whole Body Hyperthermia (FRWBH).
Scope of the Article: Biomedical Computing